慢性安定性喘息の睡眠中の不規則な呼吸と低酸素症
Lancet (London, England)
|February 6, 1982
まとめ
安定した喘息患者は,睡眠の質が低下し,睡眠中に,特にレム睡眠中に,より多くの覚醒と頻繁な酸素不飽和 (SaO2) を経験します. これらの夜間呼吸と酸素レベルの変化は,昼間のSaO2と関連していますが,肺機能の低下とは関係ありません.
科学分野:
- 呼吸器医学とは
- スリープ・サイエンス スリープ・サイエンス
- 肺生理学 肺生理学とは
背景:
- 喘息の管理は,しばしば昼間の症状に焦点を当て,夜間の障害にはあまり注意を払わない.
- 慢性呼吸器疾患の個体では,睡眠の質と酸素飽和度が著しく影響を受ける可能性があります.
研究 の 目的:
- 呼吸パターン,動脈の酸素飽和度 (SaO2),および安定した喘息患者の睡眠段階を,睡眠中の健康な対照群と比較するために.
- 成人の喘息患者の夜間低酸素症の発生と特徴を調査する.
主な方法:
- ポリソムノグラフィは,10人の安定した喘息患者と10人の年齢に匹敵する健康な被験者の呼吸,SaO2,および電気脳図 (EEG) の睡眠段階を監視するために使用されました.
- 継続的なモニタリングは,一晩中,無邪気な睡眠で実施されました.
主要な成果:
- 喘息患者は,健康な対照群と比較して,睡眠の質が低下し,覚醒,眠気,不規則な呼吸が増加することが特徴でした.
- 喘息患者は,SaO2の低下がより大きく,より頻繁に見られ,ほとんどの低血圧エピソードは,急速眼球運動 (REM) の睡眠中に発生しました.
- 夜間低酸素症の重度は,覚醒時のSaO2レベルと相関しているが,睡眠後の強制呼吸量 (FEV) の減少とは相関していない.
結論:
- 安定した喘息の患者は,主にレム睡眠中に,睡眠の質が低下し,夜間酸素不飽和に苦しんでいます.
- これらの睡眠関連の呼吸器系障害は,ベースラインの酸素供給と関連しているが,睡眠後の急性肺機能低下とは必ずしも関連していない.
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