ベクロメタゾーン二プロピオネート溶液は,クッシング症候群または下垂体下垂体副腎抑制を引き起こすことなく,炎症性腸疾患の治療のために使用されます
Lancet (London, England)
|March 13, 1982
まとめ
ベクロメタゾーン二プロピオネート (BDP) エネマは,炎症性腸疾患の治療に安全な代替案を提供し,クッシング症候群や下垂体副腎 (HPA) 抑制を引き起こすことなく,症状を効果的に管理します.
科学分野:
- 胃腸内科 胃腸内科
- エンドクリノロジー エンドクリノロジー
- 薬理学 薬理学とは
背景:
- ベクロメタゾン二プロピオネート (BDP) は,局所的作用の可能性のある強力なグルココルチコイドです.
- システミック吸収とクッシング症候群や強力なグルココルチコイドによるHPA抑制などの副作用に関する懸念があります.
研究 の 目的:
- ディスタル炎症性腸疾患 (IBD) の治療におけるBDPエネマの安全性と有効性を評価する.
- 従来のベタメタゾンの溶液栓と比較して,BDP溶液栓がカッシング症候群またはHPA抑制を引き起こすかどうかを判断する.
主な方法:
- ディスタルIBDの悪化を患っている患者を対象とした二重盲検,ランダム化研究.
- 臨床的,シグモイドスコープ的,腎上皮質機能の評価 (コシントロピン検査) 2週間のエネマコース後.
- パイロット研究におけるBDPエネマの安定性と治療的濃度の評価.
主要な成果:
- BDPとベタメタゾンのエンエマは,同様の臨床的およびシグモイドスコーピ的利点を示しました.
- BDP エネマのみが,下垂体副腎 (HPA) 軸の機能に干渉しなかった.
- ベタメタゾン注水剤に依存していた患者は,BDP注水剤に切り替えると,症状のコントロールと副作用の回復を経験しました.
結論:
- BDP エネマは,遠部炎症性腸疾患の安全で効果的な治療法です.
- BDPエネマは,HPA抑制やキュッシング症候群の全身的な副作用なしに治療的効果を提供します.
- BDPエネマは,IBDのために長期にわたるグルココルチコイド治療を必要とする患者にとって有効な代替手段です.
関連する概念動画
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:17Drugs for Treatment of Diarrhea-Predominant IBS
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
01:21Drugs for Treatment of Constipation-Predominant IBS
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
01:29Drugs for Treatment of Ulcerative Colitis in IBD
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation.
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...