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アミトリプチリンは,モノアミン酸化酵素阻害剤の"チーズ"反応を防ぐのでしょうか?
Lancet (London, England)
|July 24, 1982
まとめ
アミトリプチリンは,モノアミン酸化酵素阻害剤 (MAOI) を服用している患者のチラミンに対するプレッサー反応を著しく低下させた. この組み合わせはチラミンに富んだ食品から身を守る可能性があるが,それでも注意が必要である.
科学分野:
- 薬理学 薬理学とは
- 神経科学は神経科学である.
- クリニカル・メディシン 臨床医学
背景:
- モノアミン酸化酵素阻害剤 (MAOI) は,チラミンに富んだ食品に対する危険な高血圧反応と関連しています.
- アミトリプチリン,ドチエピン,トリミプラミンなどの三環抗うつ薬 (TCA) は一般的に処方されています.
- チラミン感受性に関するTCAとMAOIの相互作用については,さらなる解明が必要である.
研究 の 目的:
- モノアミノ酸化酵素阻害剤 (MAOI) を服用している患者におけるチラミン圧縮反応に対する異なる三環抗うつ剤 (アミトリプチリン,ドティエピン,トリミプラミン) の効果を調査する.
- ティラミン誘発性高血圧危機を緩和するためにMAOIとアミトリプチリンを併用する可能性を評価する.
主な方法:
- MAOIを投与された患者には,静脈内チラミンが投与された.
- チラミンに対する圧力器の反応は,アミトリプチリン,ドチエピン,トリミプラミン投与前後に測定された.
主要な成果:
- アミトリプチリンは,マオイ阻害剤を投与された患者で,静脈内チラミンに対するプレッサー応答を著しく低下させた.
- ドチエピンとトリミプラミンは,この患者群でチラミン感受性に対する影響は最小限であった.
- アミトリプチリンとMAOIの組み合わせは,控えめな投与量で開始し,徐々に増加することで,チラミンを含む食品に対する保護を提供することができます.
結論:
- アミトリプチリンは,MAOIで治療された患者でチラミン誘発の圧力反応に対する保護効果を示しています.
- アミトリプチリンはリスクを軽減する可能性がありますが,MAOIを服用している患者は,潜在的全身吸収のためにティラミンに富んだ食品を避けるべきです.
- アミトリプチリンとMAOIの併用療法における最適な投与戦略に関するさらなる研究が必要である.
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