妊娠の連続した段階における母性赤毛の確認の結果
Lancet (London, England)
|October 9, 1982
まとめ
妊娠中の,特に最初の3ヶ月間の母性赤血球感染症は,乳児における先天性赤血球症候群のリスクを大幅に高めます. 妊娠初期に発生する赤血球は,重症な先天性欠陥の最大の脅威である.
科学分野:
- 産婦人科と産婦人科を担当しています.
- 小児科は小児科です.
- 感染症 感染症は感染症です.
背景:
- 生まれながらの赤毛症候群 (CRS) は,赤毛ワクチン接種プログラムにもかかわらず,依然として懸念事項です.
- 異なる妊娠年齢における母性赤血球に関連した正確なリスクを理解することは,産前ケアと公衆衛生戦略にとって極めて重要です.
研究 の 目的:
- 生まれながらの赤血球感染症の頻度およびそれに関連する先天性欠陥の発生率を将来的に評価する.
- 妊娠中の母性赤毛感染症のタイミングと胎児/乳児のアウトカムとの関係を決定する.
主な方法:
- ルベッラ感染が確認された1,000人以上の妊婦の将来のフォローアップ.
- 2歳までの感染した母親から生まれた乳児の臨床および血清学的評価.
- 感染した乳児と感染しなかった乳児のアウトカムの比較.
主要な成果:
- 先天性感染症の発生率は,妊娠の最初の12週間で最も高く (80%以上),13〜14週に54%に低下し,第2 trimesterの終わりまでに25%に減少しました.
- 11週前に感染したすべての乳児は,主に先天性心疾患と聴覚障害である赤血球の欠陥を示しました.
- 13~16週間に感染した乳児の35%に欠陥,主に聴覚障害が発生し,16週後に感染した乳児には欠陥は見られなかった.
結論:
- 妊娠初期における母性赤血球感染症は,重度の先天性欠陥の重大なリスクを伴う.
- 妊娠中の赤毛の継続的な監視は,ワクチン接種プログラムの有効性を監視し,リスクのある妊娠を特定するために不可欠です.
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