食物不耐性:イライラ性腸症候群の病原性における主要な要因
Lancet (London, England)
|November 20, 1982
まとめ
特定の食品は,多くの患者で刺激性腸症候群 (IBS) の症状を誘発します. この研究は,IBS患者における食物不耐性が,直腸プロスタグランジンE2 (PGE2) 産生の増加と関連していることを確認しています.
科学分野:
- 胃腸内科 胃腸内科
- クリニカル・ニュートリション
- 免疫学 免疫学とは
背景:
- 刺激性腸症候群 (IBS) は,一般的な胃腸疾患である.
- IBSの症状を誘発する特定の食品を特定することは,依然として臨床的な課題です.
研究 の 目的:
- IBSの病原性における特定の食物不耐性の役割を調査する.
- 食物に起因するIBS症状に関連した潜在的なバイオマーカーを探求する.
主な方法:
- 21人のIBS患者は,食品チャレンジテストを受けた.
- ダブルブラインド,プラセボ制御の食品チャレンジは,患者のサブセットで実施されました.
- 測定対象には,血糖,ヒスタミン,免疫複合体,血液濃度,エオシノフィルの数,呼吸水素,および直腸プロスタグランジンE2 (PGE2) が含まれていた.
主要な成果:
- 21人の患者のうち14人に,特定の食品がIBSの症状を誘発した.
- 食品不耐性は,ダブルブラインドチャレンジで6人の患者で確認されました.
- プラズマのグルコース,ヒスタミン,免疫複合体,ヘマトクリット,エオシノフィルの数,呼吸水素の有意な変化は観察されなかった.
- 食の挑戦の後,直腸PGE2レベルが著しく上昇しました.
- 5人の患者で,直腸PGE2が湿った便の体重と相関した.
結論:
- 食物不耐性は,IBSの症状発生における重要な要因である.
- 経口プロスタグランジンE2 (PGE2) の増加は,IBSにおける食物不耐症と関連しています.
- PGE2はIBSの病理生理学に役割を果たし,潜在的に排泄習慣に影響を与える可能性があります.
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