トレードミルのエクササイズテストは,ヒドロクロロチアジドおよびベータブロック薬で治療された高血圧患者で実施されました
JAMA
|July 1, 1983
まとめ
薬を服用しても,高血圧患者は運動中に静脈動脈血圧上昇を示すことが多い. この運動による上昇は,冠動脈疾患と間違ってはならない.
科学分野:
- 心臓病学 心臓病学
- 高血圧管理 高血圧管理について
- 運動生理学 運動生理学
背景:
- ヒドロクロロチアジドは,高血圧に対する一般的な第一線治療である.
- 標準血圧を達成するために,追加の薬が必要になる患者もいます.
- ベータブロッカーは,アドオン療法として頻繁に使用されます.
研究 の 目的:
- ハイドロクロロチアジドとベータブロッカーで休息時の正常血圧に治療された高血圧患者における運動による血圧応答を評価する.
- これらの患者で運動中にダイアストリック血圧が上昇するかどうかを判断するには,冠動脈動脈硬化症を示す.
主な方法:
- ヒドロクロロチアジド単独でコントロールできない高血圧の12人の患者を研究した.
- トレードミルのエクササイズテストは,ベータブロッカーを加える前と後に行われました.
- 運動中にシストリックとダイアストリックの血圧と心拍数をモニターした.
主要な成果:
- ダブル製品 (ピーク血圧×ピーク心拍数) は,治療後に著しく減少しました.
- 休息時の正常血圧にもかかわらず,12人の患者のうち10人は,運動中に静止血圧の上昇を示した.
- 7人の患者では,運動によるダイアストリック血圧が100mmHg以上に達した.
結論:
- ヒドロクロロチアジドとベータブロッカーで静止状態の正常血圧を達成した高血圧患者では,運動中にしばしば,気圧上昇が顕著である.
- これらの患者の体圧上昇は冠動脈動脈硬化症の兆候ではない.
- 運動に対する動脈血圧の反応を評価することは,抗高血圧治療の有効性を評価する上で極めて重要です.
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