第2の活性ペプチド (ペプチドヒスティジン・イソルエウシン) の共分泌に関連したヴィーポマ患者の下痢は,単一のコーディング遺伝子によって説明される
Lancet (London, England)
|November 19, 1983
まとめ
血管活性性腸内ペプチド (VIP) とペプチドヒスティジン・イソルエウシン (PHI) は,VIPoma腫瘍で共産される. この発見は,単一のニューロンが1つの神経伝達物質のみを生成するという長年の信念に異議を唱えます.
科学分野:
- 神経内分泌学の神経内分泌学
- 分子生物学は分子生物学である.
- 腫瘍学 腫瘍学
背景:
- ペプチドヒスティジンイソルエウシン (PHI) は,哺乳類における血管活性腸内ペプチド (VIP) と同一に分布しています.
- 高いVIPレベルは,内分泌腫瘍の一種であるVIPomaと関連しています.
研究 の 目的:
- VIPoma患者のPHIとVIPの共産を調査する.
- PHIとVIPは,VIPオームの同じ細胞によって生成されているかどうかを判断する.
- PHIとVIPの共同制作の遺伝的基盤を分析する.
主な方法:
- 患者におけるプラズマVIPおよびPHI型の免疫反応性の測定.
- VIPomaの組織の免疫細胞化学分析.
- 腫瘍サンプルからのメッセンジャーRNA (mRNA) 配列解析.
主要な成果:
- VIPomaの患者は,一貫して高いレベルのVIPとPHIのような免疫反応を示した.
- 免疫細胞化学は,PHIとVIPがVIPoma組織内の同じ細胞によって生成されていることを確認しました.
- mRNA分析は,同じ腫瘍内のVIPとPHIのようなペプチドのコード配列を別々に明らかにした.
結論:
- 一つの細胞は,VIPとPHIという2つの異なる調節性ペプチドを生成することができ,これは1つの神経伝達物質1つのニューロン学説に異議を唱えます.
- VIPomaにおけるVIPとPHIの共同生産は,ペプチド調節の新しいメカニズムを示唆しています.
- この発見は,神経内分泌腫瘍の生物学と神経細胞のコミュニケーションを理解するための意味を持つ.
さらに関連する動画
09:34Targeted Next-generation Sequencing and Bioinformatics Pipeline to Evaluate Genetic Determinants of Constitutional Disease
Published on: April 4, 2018
08:24Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
Published on: May 2, 2018
関連する概念動画
01:47Pleiotropy
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
01:17Drugs for Treatment of Diarrhea-Predominant IBS
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
01:17Irritable Bowel Syndrome I: Introduction
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
01:30Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
01:28Amebiasis
Entamoeba histolytica, a protozoan parasite, is responsible for intestinal and extraintestinal amebiasis. Though a significant proportion of infections remain asymptomatic, approximately 50 million individuals annually are estimated to present with clinical disease, resulting in up to 100,000 deaths globally. The disease burden is disproportionately high in regions with lower socioeconomic status, such as parts of India, Africa, Mexico, and Latin America.Etiology and TransmissionThe infective...
01:23Irritable Bowel Syndrome
DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility PatternsDisordered...