ニコチン酸によるコレラの流体損失の減少:ランダム化対照試験
Lancet (London, England)
|December 24, 1983
まとめ
ニコチン酸は,重度のコレラ患者の腸内液体の損失を効果的に軽減しました. 2gの投与量は,コントロールと比較して,流体損失と便の排出量を減らすのに有意な利点を示しました.
科学分野:
- クリニカル・メディシン 臨床医学
- 薬理学 薬理学とは
背景:
- 重度のコレラは,かなりの腸内分泌と液体の損失を引き起こします.
- 既存の治療法は,液体と電解質のバランスを管理することを目的としています.
研究 の 目的:
- 重度のコレラにおける腸内分泌の減少におけるニコチン酸の有効性を評価する.
- 治療効果のための最適な用量を決定するために.
主な方法:
- 重度のコレラに罹患した62人の成人の患者を対象としたランダム化制御試験.
- ニコチン酸の1gまたは2gを口服で29人の患者に分けて投与した.
- 33人の対照患者との流体損失と便出荷の比較.
主要な成果:
- 2gのニコチン酸の投与量は,治療後の最初の16時間 (p<0.01とp<0.05) において,流体損失を著しく減少させた.
- 薬剤特異的な便の減少は,最初の16時間で31%から47%の範囲であった.
- 2gの投与量は1gの投与量よりも有意に有効であり,治療開始後8〜16時間後にピーク抑制が観察されました.
- ニコチン酸はよく耐えており,1人の患者に一時的な赤みが報告されました.
結論:
- ニコチン酸は,特に2gの投与量では,重度のコレラで腸内分泌を減少させる有望な薬剤です.
- 更に研究が進めば,コレラ管理における補助療法としての役割が明らかにされるかもしれない.
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