インスリン依存型糖尿病患者の影響を受けていない親族における変動性小島細胞自身免疫
Lancet (London, England)
|April 7, 1984
まとめ
補足固定小島細胞抗体 (CF-ICA) は,第1型糖尿病の親戚における活性性インスチル炎を示す. 抗体陽性の人によっては糖尿病を発症したが,多くは発症せず,予防的な免疫抑制の決定のために使用することを制限した.
科学分野:
- 免疫学 免疫学とは
- エンドクリノロジー エンドクリノロジー
- 糖尿病学 糖尿病学
背景:
- 1型糖尿病 (T1D) には重要な遺伝的要素があります.
- T1D患者の一級親族はリスクが高くなります.
- アイレット細胞抗体 (ICA) は,自己免疫性臓β細胞破壊のマーカーである.
研究 の 目的:
- 1型糖尿病の発症に対する補完体固定小島細胞抗体 (CF-ICA) の予測価値を評価する.
- T1D患者の親族におけるCF-ICA陽性の自然経歴を評価する.
主な方法:
- 将来の5年間のフォローアップ研究.
- T1Dを患っている子供の1度目の無感染の親戚のCF-ICA検診.
- 時間の経過によるグルコース耐性および抗体状態のモニタリング.
主要な成果:
- CF-ICAは685人の親族のうち20人 (2.9%) で検出されました.
- CF-ICA陽性の20人のうち,7人が5年以内にT1Dを発症しました.
- 12人はCF-ICAを失い,糖尿病を発症しなかった; 1人は抗体陽性だったが,正常血糖であった.
結論:
- CF-ICAはアクティブ・インスル炎のマーカーですが,T1Dの発症を決定的に予測することはできません.
- CF-ICAの存在だけでは,予防的な免疫抑制から恩恵を受ける個人を特定するのに不十分です.
- T1Dの予防のためのリスクの階層化を精密にするために,さらなる研究が必要である.
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