重度のパラセタモール (アセトアミノフェン) 過量投与の治療における経口メチオニンの使用
Lancet (London, England)
|October 16, 1976
まとめ
メチオニンは30人の患者でパラセタモールによる肝損傷を効果的に軽減しました. この治療法では死亡や合併症は認められず,アセトアミノフェンの過剰投与管理の安全な代替手段であると考えられる.
科学分野:
- 肝臓病理学 肝臓病理学
- 臨床毒理学 臨床毒理学とは
- 薬理学 薬理学とは
背景:
- パラセタモール (アセトアミノフェン) の過剰投与は,急性肝損傷の主要な原因です.
- 現在の治療には,限界と潜在的な副作用があります.
- 新しい治療薬の探索は,アセトアミノフェンの毒性の管理に不可欠です.
研究 の 目的:
- パラセタモールの過剰投与による肝臓損傷のリスクのある患者における経口メチオニンの有効性と安全性を評価する.
- システアミンなどの既存の治療法の代替としてメチオニンの可能性を評価する.
主な方法:
- パラセタモールの過剰投与を受けた30人の患者からなるコホートは,経口メチオニン (最大10g,最大4時間毎に2〜5g) を受けた.
- メチオニンの初期投与量は,過剰摂取から10時間以内に投与された.
- 臨床的アウトカムとプラズマアスパルテートアミノトランスフェラゼ (AST) 濃度がモニタリングされました.
主要な成果:
- 治療を受けた患者で死亡または肝臓脳症は報告されていません.
- 血のAST濃度は,30人の患者のうち21人の場合,正常な範囲内に留まっていました.
- メチオニンの投与は,肝臓損傷マーカーを軽減するように見えた.
結論:
- 経口メチオニンは,パラセタモール誘発性肝損傷の発生率と重症度を減らすのに有効である可能性があります.
- メチオニンは,アセトアミノフェンの過剰摂取の管理に有望で無毒な代替品です.
- これらの発見を確認するために,さらなる臨床試験が必要である.
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