プロプラノロルの有効性は,運動によって引き起こされるまたは増幅された心室外子宮活動制御におけるプロプラノロルの有効性
Circulation
|January 1, 1978
まとめ
プロプラノロルは,冠動脈疾患を含むほとんどの患者で,運動による心室内外症を効果的に軽減しました. 異なる投与経路では同様の有効性が示され,血濃度は結果と相関しませんでした.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- 運動は,心室内外症を引き起こすか,悪化させる可能性があります.
- ベータアドレナージックブロックは,潜在的な治療戦略です.
研究 の 目的:
- プロプラノロルの運動誘発性心室内外症の軽減における有効性を評価する.
- 異なるプロプラノロル投与経路を比較するために.
主な方法:
- 冠動脈疾患を患っている6人を含む16人の男性患者がプロプラノロール療法を受けた.
- 投与量は最大ベータ-アドレナergic ブロックのために定位されました.
- 運動テストと外科医によるモニタリングが行われました.
主要な成果:
- プロプラノロルは,10/15人の患者で運動による心室内外症を有意に減少させた (P<0.001).
- 効果は,冠動脈疾患 (P <0.02) を有する5〜6人の患者で観察されました.
- 静脈のカップレットと低心拍は,いくつかの患者で廃止され,投与経路は同様の効果を示した.
結論:
- プロプラノロールは,運動による心室内外皮症の管理に有効です.
- 経口および静脈内プロプラノロールは,比較可能な有効性を示しています.
- 健診モニタリングは,エクトピーの重症度を運動テストと比較して過小評価することがあります.
関連する概念動画
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