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Updated: Aug 17, 2026

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

ベータ-グルキュロニダゼがベンゾ (a) ピレン-3-グルキュロニドを触媒化して水解し,DNAに結合する

N Kinoshita, H V Gelboin

    Science (New York, N.Y.)
    |January 20, 1978
    PubMed
    まとめ

    ベータ-グルキュロニダゼはベンゾ[a]ピレン結合体をDNA結合誘導体に変換する. これは,ベンゾ[a]ピレンへの最初の曝露から遠く離れた場所での潜在的な発がん性を示唆しています.

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