関連する実験動画

Updated: May 5, 2026

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice
09:08

Retroviral Transduction of Bone Marrow Progenitor Cells to Generate T-cell Receptor Retrogenic Mice

Published on: July 11, 2016

8.8K

人間のT細胞抗原受容体は,完全なV遺伝子を生成するために再編成される変数,多様性,結合遺伝子セグメントによってコード化されています

G Siu, S P Clark, Y Yoshikai

    Cell
    |June 1, 1984
    PubMed
    まとめ

    研究者らは,T細胞抗原受容体内の新しい遺伝子セグメントを特定し,免疫グロブリン多様性 (D) 遺伝子に類似しています. この発見は,免疫グロブリン重鎖変異遺伝子に似た3つの部分V(D) J遺伝子組立メカニズムを明らかにしています.

    さらに関連する動画

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain08:48

    Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain

    Published on: October 25, 2016

    7.8K
    Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs11:21

    Streamlined Single Cell TCR Isolation and Generation of Retroviral Vectors for In Vitro and In Vivo Expression of Human TCRs

    Published on: September 10, 2017

    9.1K

    関連する概念動画

    Viral Recombination00:57

    Viral Recombination

    Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
    22.3K
    Cells of the Adaptive Immune Response01:23

    Cells of the Adaptive Immune Response

    The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
    6.9K
    Antigens Involved in Adaptive Immunity01:26

    Antigens Involved in Adaptive Immunity

    An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
    Complete Antigens
    Complete antigens possess both immunogenicity and...
    1.7K
    Diversity of Antigen Receptors01:28

    Diversity of Antigen Receptors

    Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
    Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
    2.1K
    T Cell Activation and Clonal Selection01:22

    T Cell Activation and Clonal Selection

    T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
    Naive T cells that have not yet encountered an antigen express two primary CD...
    13.7K
    B Cell Activation and Differentiation01:24

    B Cell Activation and Differentiation

    The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
    When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
    14.4K