関連する実験動画

Updated: May 11, 2026

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal
08:01

Oct4GiP Reporter Assay to Study Genes that Regulate Mouse Embryonic Stem Cell Maintenance and Self-renewal

Published on: May 30, 2012

10T1/2細胞からの安定したメソダーマ幹細胞系統の5-アザチチジン誘導:決定を制御する規制遺伝子の証拠

S F Konieczny, C P Emerson

    Cell
    |October 1, 1984
    PubMed
    まとめ

    5-アザチチジンはマウスの胚性幹細胞を誘導し,筋肉,軟骨,脂肪の3つの異なる系統を形成させます. この表遺伝子薬は,細胞の決定と分化を制御する重要な調節遺伝子を明らかにします.

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    De Novo Generation of Somatic Stem Cells by YAP/TAZ13:05

    De Novo Generation of Somatic Stem Cells by YAP/TAZ

    Published on: May 7, 2018

    A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells08:01

    A Two-Step Strategy that Combines Epigenetic Modification and Biomechanical Cues to Generate Mammalian Pluripotent Cells

    Published on: August 29, 2020

    関連する概念動画

    Determination01:51

    Determination

    During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
    Multipotency of Hematopoietic Stem Cells01:19

    Multipotency of Hematopoietic Stem Cells

    The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
    Lineage Commitment01:21

    Lineage Commitment

    Commitment is the  process whereby stem cells:
    Maintenance of the ES Cell State01:14

    Maintenance of the ES Cell State

    The cells of the blastocyst inner cell mass only remain pluripotent for a short time. This state of pluripotency and self-renewal can be maintained in embryonic stem (ES) cell culture by adding specific chemicals or growth factors to ensure the cells can continue dividing and later differentiate into different cell types. In some cases, the cells are grown on a feeder layer of differentiated cells, which provides the growth factors and extracellular matrix components necessary for stem cell...
    Somatic to iPS Cell Reprogramming01:29

    Somatic to iPS Cell Reprogramming

    Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012 for this...