関連する実験動画

Updated: Jun 11, 2026

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes
08:44

Generation and Purification of Human INO80 Chromatin Remodeling Complexes and Subcomplexes

Published on: October 23, 2014

中間性線維の遺伝子の構造の驚くべき保存

D Marchuk, S McCrohon, E Fuchs

    Cell
    |December 1, 1984
    PubMed
    まとめ

    研究者らは,ヒトのケラチン遺伝子を分離し,配列化し,それをヴィメンチン遺伝子と比較した. 彼らは,配列の柔軟性と驚くべきイントロンの位置にもかかわらず,中間線維タンパク質の遺伝子構造が保存されていることを発見しました.

    さらに関連する動画

    Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications09:29

    Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

    Published on: May 18, 2017

    An Integrated Approach for Microprotein Identification and Sequence Analysis09:37

    An Integrated Approach for Microprotein Identification and Sequence Analysis

    Published on: July 12, 2022

    関連する概念動画

    Adaptability of Cytoskeletal Filaments01:12

    Adaptability of Cytoskeletal Filaments

    The cytoskeleton is a complex dynamic structure performing varied functions based on cellular requirements. The adaptability of the individual filaments in the cytoskeleton determines their ability to perform various functions within the cell. It can undergo rapid reorganization during processes like cell division or remain stable for several hours as in the interphase. The adaptability of these filaments depends on stringent regulatory mechanisms. The microfilament and microtubules of the...
    Generation of Straight or Branched Actin Filaments01:14

    Generation of Straight or Branched Actin Filaments

    The straight or branched structure formation of actin filaments is controlled by nucleating proteins such as the formins and Arp2/3 complex. Formin-mediated assembly results in straight filaments, whereas Arp2/3 protein complex-mediated assembly results in branched actin filaments.
    Arp2/3 Complex
    Arp2/3 complex is a seven-subunit complex consisting of two proteins similar to actin- Arp2 and Arp3, and five other subunits that help keep Arp2 and Arp3 inactive. When required, the complex is...
    The Structure of Intermediate Filaments01:19

    The Structure of Intermediate Filaments

    The intermediate filaments are one of three widely studied cytoskeletal filaments. They are so named as their diameter (10 nm) is in between that of microfilaments (7 nm) and the microtubules (25 nm).  These filaments are highly stable and can remain intact when exposed to high salt concentrations and detergents. These filaments are responsible for providing stability and mechanical support to the cells. They also help in cell adhesion and maintaining tissue integrity.
    Intermediate filaments...
    Types of Intermediate Filaments01:31

    Types of Intermediate Filaments

    The intermediate filaments are an essential component of the cytoskeleton. Presently six types of intermediate filament have been identified. Type I and II are acidic and basic keratin proteins. Type III is of mesodermal origin and comprises four proteins: vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Vimentin is commonly found in mesenchymal cells, desmin in muscle cells, GFAP in astrocytes, while peripherin is found in peripheral nervous system neurons (PNS). Type...
    Formation of Intermediate Filaments00:57

    Formation of Intermediate Filaments

    Intermediate filaments are cytoskeletal proteins with higher tensile strength and flexibility than microfilaments and microtubules. Unlike the other two cytoskeletal proteins, intermediate filament formation lacks the enzymatic activity to hydrolyze nucleotides like ATP and GTP to generate energy for polymerization. Therefore, the formation of intermediate filaments is multistep self-assembly. The involvement of any accessory proteins in intermediate filament formation has not yet been reported.
    Disassembly of Intermediate Filaments01:35

    Disassembly of Intermediate Filaments

    Intermediate filaments (IFs) do not undergo spontaneous disassembly. Enzymes, kinases, and phosphatases add and remove phosphates from specific sites to regulate their disassembly. The IF concentration in the cytoplasm also regulates the disassembly. If the concentration crosses a threshold, it activates the protein kinases in the vicinity, allowing the phosphorylation of IFs.
    Keratin proteins, found at the cell periphery near cell junctions, undergo a cycle of assembly and disassembly. In Type...