イギリスの公務員における喫煙やその他の冠動脈疾患のリスク要因
Lancet (London, England)
|November 6, 1976
まとめ
喫煙,高血圧,高コレステロールは,冠動脈疾患 (CHD) 死亡率の重要な危険因子です. これらの要因は,他のリスク要因が制御されている場合でも,独立して心臓死のリスクを増やす.
科学分野:
- 心血管伝染病学 心血管伝染病学
- 予防性心臓病学 予防性心臓病学
- 公衆衛生研究 公共衛生研究
背景:
- 冠動脈性心疾患 (CHD) は,世界中で死亡の主な原因であり続けています.
- 変更可能な危険因子を特定することは,効果的な予防戦略にとって極めて重要です.
- 以前の研究では,ライフスタイルと生理学的要因とCHDとの関連が示唆されましたが,長期的な独立した効果については,さらなる解明が必要です.
研究 の 目的:
- 様々な生理学的およびライフスタイル要因と冠動脈性心疾患 (CHD) 死亡率のリスクとの長期的な関連を調べる.
- 喫煙,血圧,血中コレステロール,血糖,体量指数の心臓病変と死亡率に対する独立した貢献を決定する.
主な方法:
- 40歳から64歳の男性イギリス公務員1万8403人を対象とした5年間の見通し調査.
- 収集されたデータには,シストリックおよびダイアストリック血圧,血中コレステロール,血糖値 (50gの負荷から2時間),体重/身長比のベースライン測定が含まれています.
- 冠動脈性心疾患 (CHD) の死亡率データを記録し,リスク要因を評価するために多変量分析を含む統計分析を行った.
主要な成果:
- 静脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈 静脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈 静脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈動脈
- 血糖値と体重/身長比は,死亡率との単純な線形関連を示さなかった.
- 多変量分析により,喫煙,血圧,コレステロールが心臓疾患および死亡率の独立したリスク要因であることが確認されました.
結論:
- 現在の喫煙は,血圧や血コレステロールレベルに関係なく,冠動脈性心疾患 (CHD) 死亡の独立した危険因子です.
- 高血圧と高コレステロールも,心臓疾患と死亡率の有意な独立した予測因子です.
- これらの発見は,CHDを予防するために,禁煙と高血圧および高コレステロール血症の管理が重要であることを強調しています.
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