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関連する概念動画

Multiple Allele Traits01:49

Multiple Allele Traits

The Concept of Multiple Allelism
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancers Originate from Somatic Mutations in a Single Cell02:21

Cancers Originate from Somatic Mutations in a Single Cell

Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Genetic Variation01:25

Genetic Variation

Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles, which...

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関連する実験動画

Updated: Jun 30, 2026

Teratoma Generation in the Testis Capsule
05:24

Teratoma Generation in the Testis Capsule

Published on: November 7, 2011

3つの異なるヒト腫瘍細胞系には,異なる腫瘍遺伝子が含まれています.

M J Murray, B Z Shilo, C Shih

    Cell
    |August 1, 1981
    PubMed
    まとめ

    研究者らは,結腸,膀,および白血病の癌細胞に,ヒトの異なった変異遺伝子を特定した. これらの遺伝子は,マウス細胞に導入されると,がん変異を引き起こし,特定の腫瘍遺伝子が腫瘍の成長を誘導することを示しています.

    科学分野:

    • 腫瘍学 腫瘍学
    • 分子生物学は分子生物学である.
    • 遺伝学 遺伝学とは

    背景:

    • 癌細胞系には,制御不能な増殖を促す遺伝的変異が宿っている.
    • 特定の腫瘍遺伝子を特定することは,がんの発達と標的型治療法を理解するために極めて重要です.

    研究 の 目的:

    • 癌と白血病の細胞系からヒトの変異遺伝子を分離し,特徴づけること.
    • 細胞変容における特定のヒトDNA配列の役割を調査する.

    主な方法:

    • マウス細胞を腫瘍細胞系からヒトDNAに感染させる.
    • ヒト配列を検出するために,繰り返しのヒトDNAプローブを使用して,ハイブリッド化アッセイを行う.
    • 二次焦点におけるDNA制限断片の分析.

    主要な成果:

    • トランスフェクションにより,ヒトDNAを含む変形したマウス細胞の焦点が得られました.
    • 再感染によって生じた二次焦点には,変異遺伝子の配列にリンクされたヒトDNA配列が含まれていた.
    • それぞれの腫瘍型から派生した二次焦点には,異なるDNA断片のセットが共通しており,独特の変容遺伝子を示唆しています.

    結論:

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    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
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    Last Updated: Jun 30, 2026

    Teratoma Generation in the Testis Capsule
    05:24

    Teratoma Generation in the Testis Capsule

    Published on: November 7, 2011

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines
    12:35

    Comparison of Three Different Methods for Determining Cell Proliferation in Breast Cancer Cell Lines

    Published on: September 3, 2016

    Transmitochondrial Cybrid Generation Using Cancer Cell Lines
    07:49

    Transmitochondrial Cybrid Generation Using Cancer Cell Lines

    Published on: March 17, 2023

    • この研究では,ヒトの大腸がん,膀がん,プロミエロサイト性白血病の細胞系からの変異遺伝子を成功裏に特定し,区別しました.
    • 調査されたすべての腫瘍細胞系には,観察された細胞変異に責任を負うユニークな変容遺伝子が含まれていた.