関連する実験動画
Updated: Jul 20, 2026
09:07
An Orthotopic Model of Murine Bladder Cancer
Published on: February 6, 2011
まとめ
ヒト膀がん腫瘍遺伝子 (EJ) は,ハーヴェイ・サルコマウイルス腫瘍遺伝子 (ras) と同型である. この発見は,特定のDNA断片に局所化され,がん発症における共通のメカニズムを示唆しています.
科学分野:
- 分子生物学は分子生物学である.
- 腫瘍学 腫瘍学
- ウイルス学 ウイルス学 ウイルス学
背景:
- レトロウイルス性腫瘍遺伝子は,がんの発症に関与している.
- トランスフェクション研究は,変形する遺伝子の配列を定義する.
- ハーヴェイ・サルコマウイルス腫瘍遺伝子 (ras) は,知られている腫瘍遺伝子である.
研究 の 目的:
- レトロウイルス腫瘍遺伝子とトランスフォーミングシーケンス間のホモロジーを調査する.
- ヒト膀癌 (EJ) の特定の腫瘍遺伝子を特定するために.
- EJ腫瘍基因とハーヴェイ・サルコマウイルス腫瘍基因 (ras) を比較する.
主な方法:
- レトロウイルス性腫瘍遺伝子とトランスフェクションで定義された変異配列のホモロジー検査.
- 人間の膀がん (EJ) の構造分析.
- トランスクリプトを検出するためのDNAプローブハイブリッド化.
主要な成果:
- ヒト膀がん (EJ) 腫瘍遺伝子は,ハーヴェイ・サルコマウイルス腫瘍遺伝子の (ras) 同型性を示しています.
- ホモロジーの領域は,EJ腫瘍遺伝子の3.0キロベースのSacI断片に限られている.
- EJとras DNAの両方のプローブは,膀がん細胞系トランスフェクタントに類似したトランスクリプトを特定しました.
結論:
- ヒト膀がん (EJ) 腫瘍遺伝子は,ハーヴェイ・サルコマウイルス腫瘍遺伝 (ras) と密接に関連しています.
- この同質性は,がんにおけるこれらの腫瘍遺伝子の共通の起源またはメカニズムを示唆しています.
- EJとras腫瘍遺伝子のさらなる研究は,がんの発症経路を明らかにすることができます.
関連する概念動画
02:38The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:20The Retinoblastoma Gene
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
01:03Rous Sarcoma Virus (RSV) and Cancer
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
02:38The Ras Gene
The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Ras is a superfamily...