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関連する概念動画

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...

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Updated: Jul 28, 2026

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells
11:42

Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells

Published on: April 7, 2017

ヒトのサルコマ細胞系に存在する変異遺伝子.

C J Marshall, A Hall, R A Weiss

    Nature
    |September 9, 1982
    PubMed
    まとめ

    研究者らは,ヒトのサルコマで新しい変異遺伝子を特定した. この遺伝子は,線維肉腫と胚性ラブドミオサルコマで見つかり,他のヒト腫瘍で以前に特定された腫瘍遺伝子とは異なっており,既知のレトロウイルス性腫瘍遺伝子とのホモロジーは欠けている.

    科学分野:

    • 腫瘍学 腫瘍学
    • 分子生物学は分子生物学である.
    • 遺伝学 遺伝学とは

    背景:

    • NIH/3T3細胞へのDNA転移は,ヒト腫瘍の変容配列を特定する.
    • 変異活性が,がんや血液学的悪性腫瘍を含む様々な腫瘍タイプで検出されています.
    • 以前特定された変容配列は,腫瘍の種類によって変化し,結腸癌と肺癌の間の重複がある.

    研究 の 目的:

    • ヒトサルコマ細胞系における変異遺伝子の存在と性質を調査する.
    • サルコマの変異遺伝子が,他のヒト腫瘍で見つかったものと類似しているかどうかを判断する.
    • サルコマ由来型変異遺伝子の,既知のレトロウイルス性腫瘍遺伝子の同質性を評価する.

    主な方法:

    • NIH/3T3細胞のDNAトランスフェクション.
    • ヒトの線維肉腫および胚性ラブドミオサルコマの細胞系からDNAを分離および分析.
    • サザンブレット分析は,レトロウイルス腫瘍遺伝子の同質性を検出します.

    主要な成果:

    • 2つの異なるヒトサルコマ細胞系 (繊維サルコマと胚性ラブドミオサルコマ) のDNAは,変容活性を示した.
    • 両方のサルコマで特定された変異遺伝子は,互いに同一であった.

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  • このサルコマ特異の変異遺伝子は,検査された8つのレトロウイルス性腫瘍遺伝子の検出可能なホモロジーを示さなかった.

    • 結論:

    • 人間のサーコマは,他の腫瘍タイプに見られるものとは異なる特定の変異遺伝子を宿している.
    • 特定された変異遺伝子は,以前に特徴づけられていない新しい腫瘍遺伝子を表しています.
    • この新しいサルコマ関連変異遺伝子の機能とメカニズムを明らかにするために,さらなる研究が必要である.