関連する実験動画

Updated: May 26, 2026

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins
05:35

Immunofluorescence Analysis of Endogenous and Exogenous Centromere-kinetochore Proteins

Published on: March 3, 2016

イーストのセントロメアDNAは,染色体と小さな円形のミニ染色体において,独特で高度に秩序付けられた構造に存在する

K S Bloom, J Carbon

    Cell
    |June 1, 1982
    PubMed
    まとめ

    イーストのセントロメアは,バルククロマチンとは異なる,保護された中央領域を持つユニークなクロマチンの構造を示します. この特殊な構造はプラズミッドに維持されるが,隣接するDNAに伝播することはない.

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    Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells

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    Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae07:48

    Use of Time-Lapse Microscopy and Stage-Specific Nuclear Depletion of Proteins to Study Meiosis in S. cerevisiae

    Published on: October 11, 2022

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    Genomic DNA in Eukaryotes00:58

    Genomic DNA in Eukaryotes

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    Chromosome Structure02:40

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    Telomeres consist of non-coding repetitive nucleotide...
    Chromatin Packaging02:21

    Chromatin Packaging

    Each human somatic cell contains 6 billion base-pairs of DNA. Each base-pair is 0.34 nm long, which means that each diploid cell contains a staggering 2 meters of DNA. How is such a long DNA strand packed inside a nucleus measuring only 10 - 20 microns in diameter? 
    The chromatin
    In combination with specialized DNA binding protein called Histones, the DNA double helix forms a compact DNA: protein complex called chromatin. The chromatin itself is further compacted into higher-order structures.
    Histone Variants at the Centromere02:30

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    Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
    Chromosome Structure02:40

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    A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
    The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
    Telomeres consist of non-coding repetitive nucleotide...
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