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Updated: Apr 25, 2026

A Familial Hypercholesterolemia Human Liver Chimeric Mouse Model Using Induced Pluripotent Stem Cell-derived Hepatocytes
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LDL受容体の翻訳後の処理と,家族性高コレステロール血症におけるその遺伝的破壊

H Tolleshaug, J L Goldstein, W J Schneider

    Cell
    |October 1, 1982
    PubMed
    まとめ

    研究者は,培養ヒト線維芽細胞における低密度リポタンパク質 (LDL) 受容体合成と処理を研究した. 彼らは,家族性高コレステロール血症における新しい処理ステップと障害を特定し,LDL受容体遺伝子変異の洞察を明らかにしました.

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