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Updated: Jul 21, 2026

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice
12:54

Transient Expression of Proteins by Hydrodynamic Gene Delivery in Mice

Published on: May 5, 2014

トランス遺伝子マウスにおける鶏のトランスリン遺伝子の発現

G S McKnight, R E Hammer, E A Kuenzel

    Cell
    |September 1, 1983
    PubMed
    まとめ

    研究者らは,鶏のトランスファーリン遺伝子をマイクロ注入することで,トランスゲンマウスを生み出した. ほとんどの子孫は鶏の遺伝子を発現し,肝臓発現と血清への分泌が優先される.

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    Lentiviral Mediated Production of Transgenic Mice: A Simple and Highly Efficient Method for Direct Study of Founders10:21

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    Overview of Transposition and Recombination

    Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
    The Ratio of X Chromosome to Autosomes02:45

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    Forced Transdifferentiation

    Transdifferentiation, also known as lineage reprogramming, was first discovered by Selman and Kafatos in 1974 in silkmoths. They observed that the moths’ cuticle-producing cells transformed into salt-producing cells. Many such cases of natural transdifferentiation occur in organisms. In humans, pancreatic alpha cells can become beta cells. In newts, the loss of the eye’s lens causes the pigmented epithelial cells to transdifferentiate into the lens cells.
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    Transposons01:24

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    Transposons, or "jumping genes," are small mobile genetic elements (MGEs) that range from 700 to 40,000 base pairs in length. They are found in all organisms and can move within the same chromosome or transfer to different chromosomes. In some cases, transposons can also jump between different host DNA molecules, such as plasmids or viruses, contributing to genetic variability.Barbara McClintock first discovered these mobile genetic elements in the 1940s while studying maize genetics, and she...