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Updated: Aug 24, 2026

Assessment of Antibody-based Drugs Effects on Murine Bone Marrow and Peritoneal Macrophage Activation
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Published on: December 26, 2017

マウスマクロファージのIgG Fc受容体の役割は,リガンド依存イオンチャネルとしての役割です

J D Young, J C Unkeless, T M Young

    Nature
    |November 10, 1983
    PubMed
    まとめ

    マウスマクロファージのFc受容体 (FcR) は,IgG2bとIgG1の免疫複合体と結合し,リガンド依存のカチオン選択イオンチャネルを形成する. これは,ファゴサイトーシスと炎症反応のシグナル伝達のための受容体-イオノフォールモデルを示唆しています.

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