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Updated: Jul 13, 2026

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells
09:49

Induction and Assessment of Class Switch Recombination in Purified Murine B Cells

Published on: August 13, 2010

免疫グロブリンDとJHセグメントのサイト固有の再結合が,ネズミのpre-B細胞系ゲノムに導入された

T K Blackwell, F W Alt

    Cell
    |May 1, 1984
    PubMed
    まとめ

    この研究では,免疫グロブリン重鎖多様性 (D) と結合 (JH) 要素の結合は,特定の染色体位置なしに起こり得ることを示しています. この過程で,チミジンキナーゼ (tk) 遺伝子が頻繁に削除され,B前細胞の薬剤耐性が生じます.

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