関連する実験動画

Updated: Aug 19, 2026

Testing Animal Anxiety in Rats: Effects of Open Arm Ledges and Closed Arm Wall Transparency in Elevated Plus Maze Test
07:54

Testing Animal Anxiety in Rats: Effects of Open Arm Ledges and Closed Arm Wall Transparency in Elevated Plus Maze Test

Published on: June 29, 2018

長期にわたるディアゼパム治療と臨床結果

K Rickels, W G Case, R W Downing

    JAMA
    |August 12, 1983
    PubMed
    まとめ

    長期にわたるディアゼパム治療は,耐性が生じることなく,室外患者の不安を効果的に軽減します. しかし,より長い治療期間 (8ヶ月以上) は,管理可能な離脱症状のリスクを高めます.

    さらに関連する動画

    Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats08:47

    Microdialysis of Excitatory Amino Acids During EEG Recordings in Freely Moving Rats

    Published on: November 8, 2018

    Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale07:35

    Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale

    Published on: July 8, 2025

    関連する概念動画

    Long-term Depression01:05

    Long-term Depression

    Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
    Psychosis: Goals of Pharmacotherapy01:26

    Psychosis: Goals of Pharmacotherapy

    Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation. For...
    Anxiolytic Drugs: Benzodiazepines and Buspirone01:29

    Anxiolytic Drugs: Benzodiazepines and Buspirone

    Benzodiazepines are a class of anxiolytic drugs known for their rapid efficacy and high therapeutic-to-lethal dose ratio, but with a potential risk of drug dependence. These drugs are lipophilic, allowing for rapid absorption after oral administration, eventually reaching the central nervous system (CNS). Once in the CNS, benzodiazepines bind to the allosteric site of the GABAA receptor. This binding enhances the inhibitory effects of the neurotransmitter GABA. By doing so, they prevent...
    Sedatives and Hypnotics Drugs: Benzodiazepines01:19

    Sedatives and Hypnotics Drugs: Benzodiazepines

    Benzodiazepines have both sedative and hypnotic properties. They include compounds such as diazepam (Valium) and alprazolam (Xanax). Structurally, their cores are similar, consisting of the fusion of a benzene ring and a diazepine ring, but they share a common mechanism of action in the central nervous system (CNS).
    Benzodiazepines work by enhancing the effects of the inhibitory neurotransmitter GABA. They bind to the GABAA receptor, increasing its affinity for GABA, which opens chloride...
    Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship01:14

    Pharmacokinetic–Pharmacodynamic Relationship: Duration of Dose-Effect Relationship

    For drugs producing a quantal response, onset occurs when plasma concentration reaches a minimum effective level (Cmin). The drug's action duration depends on how long the plasma concentration remains above Cmin.Two primary factors influence this duration: dose size and the rate of drug removal from the action site. Both depend on the drug's redistribution to poorly perfused tissues and elimination processes. A larger dose promotes rapid onset and prolongs the effect's duration.Consider a...
    Drug Therapy01:28

    Drug Therapy

    The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
    Antianxiety Medications