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Updated: Aug 3, 2026

Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli
07:04

Site-Directed Mutagenesis for In Vitro and In Vivo Experiments Exemplified with RNA Interactions in Escherichia Coli

Published on: February 5, 2019

信号配列の変異は,輸出されたタンパク質の分泌と,E. coliにおけるその合成の間のフィードバックを乱します

C A Kumamoto, D B Oliver, J Beckwith

    Nature
    |April 2, 1984
    PubMed
    まとめ

    タンパク質の分泌を阻害すると,タンパク質合成が止まります. マルトース結合タンパク質の信号配列を修正することで,Escherichia coli secA変異体におけるこの合成ブロックが防止され,分泌機構による信号配列認識が確認されました.

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