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関連する概念動画

Protein Digestion01:02

Protein Digestion

Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...
Anoxygenic Phototrophic Bacteria01:28

Anoxygenic Phototrophic Bacteria

Anoxygenic phototrophic bacteria are a diverse group of microorganisms that perform photosynthesis without producing oxygen. They primarily include purple sulfur bacteria, purple nonsulfur bacteria, green sulfur bacteria, and green nonsulfur bacteria. These bacteria are classified into the Gammaproteobacteria, Alphaproteobacteria, Betaproteobacteria, Chlorobi, and Chloroflexi lineages, each with distinct physiological and ecological adaptations.Purple sulfur bacteria belong to the...
Production of Organic Acids01:25

Production of Organic Acids

Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
Production of Antibiotics01:27

Production of Antibiotics

Penicillin, one of the earliest and most widely used antibiotics, is produced industrially by the filamentous fungus Penicillium chrysogenum. Large stirred-tank bioreactors ranging from tens to hundreds of thousands of liters maintain tightly controlled temperature, pH, and dissolved oxygen conditions to support fungal metabolism and maximize antibiotic yield. Penicillin is a secondary metabolite, synthesized primarily during the stationary growth phase, which requires a carefully managed...

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関連する実験動画

Updated: Jul 26, 2026

Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock
07:24

Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock

Published on: June 29, 2017

リバプールのペニシリナーゼ生成性ゴノコチ菌.

A Percival, J Rowlands, J E Corkill

    Lancet (London, England)
    |December 25, 1976
    PubMed
    まとめ

    ペニシリナーゼを産生するゴノコックスは1976年に出現し,ペニシリン治療は効果的にならなかった. スペクトノミシンは高い成功率を示したが,ペニシリネーゼに安定したセファロスポリンには,将来の淋病の治療に希望がある.

    科学分野:

    • 微生物学 微生物学とは
    • 感染症 感染症は感染症です.
    • 抗菌剤耐性菌は,抗菌剤耐性菌である.

    背景:

    • イギリスでペニシリネーゼ産生性ネイセリア・ゴノレア (PPNG) 菌株の出現.
    • PPNG菌株は,グラム陰性バシリに多く見られるTEM型ペニシリナーゼを獲得した.
    • PPNGの孤立種は急速に普及し,1976年までにリヴァプールで9%に達した.

    研究 の 目的:

    • PPNG感染の臨床的影響を評価する.
    • PPNGに対する異なる抗菌剤の有効性を評価する.
    • 診断検査と代替治療の必要性を強調する.

    主な方法:

    • PPNGに感染した45人の患者の臨床観察.
    • ペニシリン,スペクトノミシン,テトラサイクリンによる治療効果評価.
    • ペニシリン酵素に安定したセファロスポリンに対するインビトロ感受性試験.

    主要な成果:

    • ペニシリンの治療は,PNG感染のすべての症例で失敗しました.
    • スペクトノミシンは95%の成功率 (21/22患者) を達成しました.
    • テトラサイクリン薬の成功率は68% (13/19患者) でした.

    さらに関連する動画

    Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
    10:01

    Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase

    Published on: December 4, 2017

    A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
    03:55

    A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

    Published on: June 27, 2022

    関連する実験動画

    Last Updated: Jul 26, 2026

    Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock
    07:24

    Production of Chemicals by Klebsiella pneumoniae Using Bamboo Hydrolysate as Feedstock

    Published on: June 29, 2017

    Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
    10:01

    Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase

    Published on: December 4, 2017

    A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
    03:55

    A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria

    Published on: June 27, 2022

  • ペニシリン酵素に安定したセファロスポリンには, in vitro の活性が示されました.
  • 結論:

    • PPNGの感染は,伝染性または侵入性の低下を示さなかった.
    • 標準的なペニシリン治療は,PPNGに対して無効です.
    • スペクトノミシンは効果的な治療法であり,ペニシリナーゼに安定したセファロスポリンが将来の潜在的な選択肢である.
    • PPNGの実験室での検出は,英国中に広がるため,非常に重要です.