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Updated: Jul 22, 2026

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
11:42

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes

Published on: November 1, 2012

アルファヘリクスを置換すると,抑制器のシーケンス固有のDNA相互作用がスイッチされます

R P Wharton, E L Brown, M Ptashne

    Cell
    |September 1, 1984
    PubMed
    まとめ

    研究者らは,バクテリオファージ434のレプレッサーおよびクロンタンパク質にDNA認識ヘリケスを特定しました. ハイブリッドタンパク質は,これらのヘリクスを交換することで,DNA結合特異性が変化し,その役割が確認されたことを示しました.

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