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Updated: May 30, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

免疫グロブリン重鎖遺伝子のクラス・スイッチ再結合領域における繰り返しの配列

T Kataoka, T Miyata, T Honjo

    Cell
    |February 1, 1981
    PubMed
    まとめ

    免疫グロブリンクラス・スイッチの再結合は,S領域内の同類の繰り返し配列によって促進されます. Sガンマ1,Sガンマ2b,Sガンマ3の領域に保存された49bp単位は,B細胞の微分化中にDNA再結合のメカニズムを示唆している.

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    Generation of Discriminative Human Monoclonal Antibodies from Rare Antigen-specific B Cells Circulating in Blood

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    Identification of Homologous Recombination Events in Mouse Embryonic Stem Cells Using Southern Blotting and Polymerase Chain Reaction08:01

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