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ネズミや霊長類の内生C型RNAウイルスのガグ遺伝子にコードされたタンパク質の進化的関係
Cell
|April 1, 1977
まとめ
バビオンとマウスの内生性C型ウイルスは,p10とp12/p15を含む,関連するガグ遺伝子タンパク質を共有しています. これは,これらのレトロウイルスの共通の進化的起源を示唆しています.
科学分野:
- ウイルス学 ウイルス学 ウイルス学
- 分子生物学は分子生物学である.
- 進化生物学の進化生物学について
背景:
- 固有のC型ウイルスは,様々な種のゲノムに組み込まれています.
- これらのウイルス,特にRD114/バビオンおよびマウリン群のウイルスは,その遺伝的および抗原的特性のために研究されています.
研究 の 目的:
- 低分子量タンパク質を比較するために,RD114/バブーンとマウリン内生C型ウイルスのガグ遺伝子によってコードされています.
- これらのウイルスタンパク質の間の免疫学的および生化学的関係を調査する.
- これらの関係がもたらす進化的影響を探求する.
主な方法:
- ウイルスタンパク質の免疫学的比較.
- ウイルスタンパク質の生化学的特徴.
- ガグ遺伝子翻訳産物の分析.
主要な成果:
- 2つのウイルス群のp10タンパク質は,免疫学的および生化学的に関連しています.
- RD114/バブンp12タンパク質は,ネズミウイルスp15.5と抗原決定素を共有しています.
- タイプ固有のフォスフォタンパク質 (RD114/バブンのp15,ネズミウイルスのp12) は,似たような生化学的性質を示している.
- ネズミのC型ウイルスのガグ遺伝子にコードされたすべてのタンパク質は,RD114/バブン群に類似している.
結論:
- RD114/baboonとマウリン内生C型ウイルスのガグ遺伝子翻訳産物は,非常に関連しています.
- これらの発見は,これらの内生レトロウイルスの進化における共通の祖先の仮説を支持する.
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