エタムボトールとイソニアジドをリファンピシンとイソニアジドと比較して,抗結核治療の継続治療において
Lancet (London, England)
|June 11, 1977
まとめ
この研究では,エタムボトールとイソニアジド (E+I) が,リファンピシンとイソニアジド (R+I) の費用対効果の高い代替品であり,結核治療の完了のために,再発なしの有効性と受容性が同じであることを示しました.
科学分野:
- 医学 医学 医学 医学 医学
- 感染症 感染症は感染症です.
- 肺内科 肺内科 肺内科
背景:
- 結核 (TB) は,世界的な健康上の大きな課題であり続けています.
- 有効で手頃な価格の治療法は,結核の予防に不可欠です.
- 標準的な結核治療は,長期間にわたって複数の薬剤を投与するものです.
研究 の 目的:
- 肺結核の2つの継続療法の有効性と受容性を比較する.
- エタンブートールとイソニアジド (E+I) とリファンピシンとイソニアジド (R+I) の費用対効果を評価する.
主な方法:
- 細菌学的陽性肺結核患者の初期治療は,イソニアジド,リファンピシン,エタンブトールでした.
- 1年間の継続治療は,R+IまたはE+Iで投与されました.
- 各グループの63人の患者は,治療後少なくとも1年間,追跡調査を行った.
主要な成果:
- R+IまたはE+I継続治療群では再発は観察されなかった.
- E+Iによる継続治療は,R+Iと同等の効果と受容性を示した.
- E+I 療法は,R+I 療法の費用より大幅に安かった.
結論:
- エタムボトールとイソニアジドは,肺結核の生存可能で,有効で,受け入れられる継続療法です.
- E+I療法は,R+Iと比較して,より経済的な治療オプションを提供します.
- これらの発見は,TB管理のための資源の限られた設定でE+Iの使用を支持します.
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