鬱病は糖尿病性神経疾患に偽装したうつ病です
JAMA
|March 21, 1980
まとめ
この研究では,下肢における痛ましい糖尿病性神経病気が,しばしばうつ病の形態であることを発見しました. イミプラミンやアミトリプチリンなどの抗うつ薬は,患者の痛みとうつの両方を効果的に治療しました.
科学分野:
- 神経学 神経学とは
- 精神科医は精神病を患っている.
- 薬理学 薬理学とは
背景:
- 糖尿病性神経症は,糖尿病の一般的な合併症です.
- 痛ましい糖尿病性神経症は,患者の生活の質に大きな影響を与えます.
- うつ病はしばしば慢性疼痛状態と併発する.
研究 の 目的:
- 痛烈な糖尿病性神経症の患者のうつ病を評価するために.
- この状態に対する抗うつ剤の薬物療法の有効性を評価する.
主な方法:
- ダブルブラインドでコントロールされた研究が行われました.
- 疼痛性糖尿病性ニューロパシーを患った59人の患者が対象となった.
- 精神科のインタビューとクッファー・デトレテストのスコアは,うつ病の評価に使用されました.
- 治療には,イミプラミン水塩化物またはアミトリプチリン水塩化物が含まれていました.
主要な成果:
- すべての患者は実質的なうつ病を発症した.
- イミプラミンまたはアミトリプチリンによる治療は,10週間以内に下肢痛の完全な寛解をもたらしました.
- 同時にうつ病症状の緩和とうつ病テストスコアの正常化が見られた.
結論:
- 下肢の痛ましい糖尿病性神経症は,多くの場合,うつ病に相当します.
- イミプラミンとアミトリプチリンは,うつ病に関連した痛ましい糖尿病性神経疾患の効果的な治療法です.
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