ディメチルスルフォキシドがヒトの腎機能に及ぼす影響
関連する実験動画
Updated: Oct 13, 2026

07:18
Transcutaneous Assessment of Renal Function in Conscious Rodents
Published on: March 26, 2016
JAMA
|November 7, 1980
まとめ
静脈内投与のディメチル硫酸化物 (DMSO) は,脊髄損傷の患者で一時的な血解とヘモグロビンウリアを引き起こす可能性があります. しかし,腎機能を損なわないため,腎臓移植の移植に適していることが示唆されています.
科学分野:
- ネフロロジーは腎臓科
- 血液学 ヘマトロジ
- 薬理学 薬理学とは
背景:
- ディメチル硫酸化物 (DMSO) は,重度の脳腫などの症状に静脈内投与されます.
- ピグメントウリア,特にヘモグロビンウリアは,知られている副作用です.
- 腎機能に対するDMSO誘発の血解の影響については,説明が必要です.
研究 の 目的:
- DMSO誘発性ピグメント尿の臨床的重要性を評価する.
- IV DMSO.を投与された患者で腎機能と全身性血解の指標を評価する.
- これらの患者を腎臓移植ドナーとして使用する安全性を判断する.
主な方法:
- 脊髄損傷のためにIVDMSOを投与された安定した四肢麻痺患者について研究した.
- 腎機能検査が行われました.
- システミック・ヘモリシスと尿液沈殿物の指標を分析した.
主要な成果:
- 投与量に依存する一時的な血解とヘモグロビンウリアが観察されました.
- 腎機能の有意な変化は検出されなかった.
- 尿堆積物分析は,ヘモグロビンを除いて,ベースラインからの変化を示さなかったし,重度の出血が起こらなかった.
結論:
- 静脈内投与のDMSOは一時的な血液溶解を引き起こすが,脊髄損傷患者では腎機能を損なわない.
- 腎臓への重大な影響がないことから,これらの患者は適切な腎臓移植ドナーである可能性が示唆されています.
関連する概念動画
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