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人間の胚の口腔のメゼンキマ細胞は,表皮成長因子に非常に反応します

T Yoneda, R M Pratt

Science (New York, N.Y.)

|July 31, 1981

まとめ

皮膚表皮成長因子 (EGF) は,ヒト胚の palatal mesenchymal 細胞の成長と主要な酵素の活動を刺激します. これは,EGFがヒトの胚および胎児の組織発達に不可欠であることを示唆しています.

科学分野:

細胞生物学細胞生物学
発達生物学発達生物学とは
バイオケミストリーバイオケミストリー

背景:

メセンキマ細胞は,組織発育に不可欠です.
皮膚表皮成長因子 (EGF) は,既知の成長調節剤である.

研究の目的:

EGFがヒト胚の palatal mesenchymal 細胞に及ぼす影響を調査する.
胚の発達におけるEGFの役割を理解するために.

主な方法:

ヒトの胚の palatal mesenchymal 細胞の確立した細胞系を利用した.
EGFに対する反応として,細胞の成長,ラベル付きのチミジン組み込み,オルニチンデカルボキシラーゼの活性を評価した.

主要な成果:

ヒト胚の palatal mesenchymal 細胞は,EGFに対して高い感受性を示した.
EGFは,細胞の成長,チミジンの組み込み,オルニチンデカルボキシラーゼの活性を著しく刺激しました.

結論:

皮膜成長因子は,ヒト胚の palatal mesenchymal 細胞の増殖と分化に重要な役割を果たします.
EGFは,ヒトの胚および胎児組織の発達における重要な要因である可能性が高い.

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