アレルギーにおける論争の的慣行
JAMA
|June 11, 1982
まとめ
いくつかのアレルギー検査方法には科学的根拠がない. 制御された研究では,皮膚内定量化,挑発性検査,自己性尿免疫療法が効果的でないか有害で,患者のケアと費用に影響を及ぼすことが示されています.
科学分野:
- 免疫学 免疫学とは
- クリニカルアレルギーのアレルギー
背景:
- 現代のアレルギー治療は,過敏症の病原性を理解することに依存しています.
- アレルギーの特定の臨床実践は,科学的調査にもかかわらず,論争の的であり続けています.
研究 の 目的:
- 論争の的なアレルギーの診断および治療手順を支持する科学的証拠を評価する.
- 証明されていないアレルギー治療の有効性とリスクについて医師に知らせる.
主な方法:
- 特定のアレルギー検査と免疫療法の方法を検討する制御試験のレビュー.
- 皮膚内滴定,挑発性検査,自己性尿免疫療法に関する証拠の評価.
主要な成果:
- 制御された研究は,免疫療法の指針として,皮膚内定量化または低レベルの改変型放射性アレルゴ吸収剤定量化をサポートしていません.
- 食物アレルギーの診断のための挑発的検査または白血球毒性アッセイの臨床的有用性を支持する証拠はありません.
- ハイパーキネシスに対する食品添加物の影響は不明である;自己性尿免疫療法には証拠が不足し,有害である可能性がある.
結論:
- 医師は,アレルギー処置の科学的根拠を理解し,患者に効果的に助言しなければなりません.
- アレルギーにおける論争の的な慣行は,経験的根拠が欠け,リスクをもたらす可能性があります.
- アレルギー性疾患の蔓延と経済的影響のために,患者に対する情報に基づいたカウンセリングは極めて重要です.
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