体重とそれに続く糖尿病
JAMA
|August 27, 1982
まとめ
肥満は,特にリスクの高い女性において,糖尿病のリスクを予測します. また,このグループにおける過剰体重は,より重度の糖尿病状態を示し,糖尿病の予測におけるリスクの階層化の重要性を強調した.
科学分野:
- エンドクリノロジー エンドクリノロジー
- メタボリック疾患
- 公衆衛生は公衆衛生である.
背景:
- 肥満は,代謝障害に関連した世界的な健康問題です.
- 糖尿病の予測マーカーは,早期介入に不可欠です.
- 妊娠中のグルコース不耐症は,将来の糖尿病の危険因子として知られています.
研究 の 目的:
- 糖尿病に対する体重の10年から16年の予測値を将来的に評価する.
- 体重過多状態が,正常なグルコース耐性テストによる女性における糖尿病発生率を予測するかどうかを評価する.
- 体重がリスクの高い個人の糖尿病の重症度を予測するかどうかを判断する.
主な方法:
- 当初,正常なグルコース耐性テストを受けた女性を対象とした前向きなコホート研究.
- 2つのグループが分析されました:高リスク (以前の一時的な妊娠性グルコース不耐症) とネガティブコントロール被験者.
- 糖尿病の発生率と重症度は10〜16年にわたって追跡され,体重は正常または過体重に分類されました.
主要な成果:
- 体重過多の高リスクの女性は,正常体重の高リスクの女性 (25.6%) と比べて,糖尿病の発生率が (46.7%) 明らかに高かった.
- 対照群では,過剰体重 (4.5%) と正常体重 (1.9%) の糖尿病発生率の違いは有意ではなかった.
- 肥満状態は,高リスク分類が存在しない限り,糖尿病の実質的な予測因子ではなかった. 過剰な体重は,高リスクの女性における糖尿病の重度の増加を予測した.
結論:
- 体重は糖尿病の発生率と重度の有意な予測因子ですが,他の高リスク要因が存在する場合に限ります.
- 肥満の状態だけでは,以前に正常なグルコース耐性を有していた女性の糖尿病を予測するのに不十分です.
- 体重と妊娠中のグルコース不耐症歴の両方を含むリスクの分層化は,糖尿病の正確な予測に不可欠です.
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