免疫学的な耐性に対するラマルコの遺伝が想定されている

L Brent, L S Rayfield, P Chandler

Nature

|April 9, 1981

まとめ

この研究では,マウスの獲得免疫耐性の遺伝性を調査した. 研究者は,免疫耐性が,男性系を通して世代を超えて伝染することを示唆する発見を複製できませんでした.

科学分野:

免疫学免疫学とは
遺伝学遺伝学とは
進化生物学の進化生物学について

背景:

ラマルコの遺伝,つまり,習得した特徴が遺伝的であるという考えは,ネオ・ダーウィンの原理に異議を唱えている.
以前の主張では,特定の抗原に対する免疫耐性がマウスの父から受け継がれることが示唆されていた.
この潜在的な世代を超えた免疫調節は,精子細胞の継続的な生産のために興味があります.

研究の目的:

既得免疫耐性の遺伝性を調査する.
抗原耐性の父からの伝播に関する発見を複製しようとする.
耐性マウスの子孫の免疫反応低下を検査する.

主な方法:

F1ハイブリッド細胞を用いたCBAマウスのA株抗原に対する耐性の誘導.
耐性のある雄マウスと正常なCBA雌マウスの交尾.
細胞媒介リンパ溶解 (CML) アッセイと皮膚アロインプラントの拒絶を in vitro 経由で子孫の免疫応答を評価する.

主要な成果:

この研究では,子孫にA株抗原に対する免疫耐性の伝播が主張されていることを確認できませんでした.
耐性のある父親の子孫は,CMLアッセイで有意な低反応を示さなかった.
また,皮膚アロ移植に対する検査は,誘発された耐性の遺伝性を支持しませんでした.

結論:

このモデルでは,得られた免疫耐性が世代を超えて父から受け継がれるという仮説を,この研究結果は支持していない.
この結果は,男性生殖系経由による世代間免疫調節に関する以前の主張に異議を唱えている.
免疫記憶のメカニズムと潜在的な表遺伝的遺伝を理解するためにさらなる研究が必要です.

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