関連する実験動画

Updated: Jan 10, 2026

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy
08:27

Expression and Purification of the Human Lipid-sensitive Cation Channel TRPC3 for Structural Determination by Single-particle Cryo-electron Microscopy

Published on: January 7, 2019

9.9K

クラスリントリマーのタンパク質組織

T Kirchhausen, S C Harrison

    Cell
    |March 1, 1981
    PubMed
    まとめ

    研究者らは,小牛の脳で覆われた膀から安定したクラトリン複合体を分離した. 重い鎖と軽い鎖から成るこの8.6Sクラスリン種は,他のタンパク質なしで,自己組み立てでケージを作ることができる.

    さらに関連する動画

    Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy12:40

    Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy

    Published on: October 20, 2014

    80.9K
    In vivo and in vitro Studies of Adaptor-clathrin Interaction17:14

    In vivo and in vitro Studies of Adaptor-clathrin Interaction

    Published on: January 26, 2011

    15.0K

    関連する概念動画

    Clathrin Coated Vesicles01:12

    Clathrin Coated Vesicles

    Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
    9.0K
    Pinching-off of Coated Vesicles01:32

    Pinching-off of Coated Vesicles

    Vesicle budding is orchestrated by distinct cytosolic proteins such as adaptor proteins, coat proteins, and GTPases. To initiate vesicle budding, membrane-bending proteins containing crescent-shaped BAR domains bind to the lipid heads in the bilayer and distort the membrane to form a protein-coated vesicle bud. Adaptors proteins such as AP2 for clathrin-coated vesicles can nucleate on the deformed membrane. Finally, coat proteins such as clathrin or COPI and COPII assemble into a coat forming...
    4.0K
    Vesicular Tubular Clusters01:45

    Vesicular Tubular Clusters

    After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
    With the help of motor proteins such...
    3.0K
    Protein Folding01:22

    Protein Folding

    Overview
    125.9K
    Protein Folding01:25

    Protein Folding

    Proteins are chains of amino acids linked together by peptide bonds. Upon synthesis, a protein folds into a three-dimensional conformation, critical to its biological function. Interactions between its constituent amino acids guide protein folding, and hence the protein structure is primarily dependent on its amino acid sequence.
    Protein Structure Is Critical to Its Biological Function
    Proteins perform a wide range of biological functions such as catalyzing chemical reactions, providing...
    11.0K
    Protein Organization01:13

    Protein Organization

    Overview
    155.6K