Streptococcus pneumoniaeはペニシリンとクロラムフェニコールに耐性がある
Lancet (London, England)
|November 12, 1977
まとめ
ペニシリン,セファロスポリン,クロラムフェニコルに耐性のある肺炎球菌は,重度の感染症を引き起こしました. 治療にもかかわらず, Meningitis の症例は致命的であり, セプシスの症例は回復し,抗生物質耐性の課題を強調しました.
科学分野:
- 微生物学 微生物学とは
- 感染症 感染症は感染症です.
- クリニカル・メディシン 臨床医学
背景:
- Streptococcus pneumoniaeの新興抗生物質耐性は,公衆衛生に重大な脅威をもたらしています.
- ペニシリン,セファロスポリン,クロラムフェニコルは,肺炎球菌感染症の治療に不可欠な抗生物質です.
研究 の 目的:
- 複数の抗生物質に耐性菌株によって引き起こされる侵入性肺炎球菌疾患の臨床症例を報告する.
- これらの耐性肺炎球菌の特徴を調査する.
主な方法:
- 臨床症例報告とレビュー.
- 病原性肺炎球菌単離物の微生物学的分析,ベータ・ラクトマース試験を含む.
主要な成果:
- 侵襲性肺炎球菌疾患の5例 (3例 Meningitis, 2例 セプチセミア) が確認されました.
- 肺炎球菌の単離はペニシリン,セファロスポリン,クロラムフェニコルに対する耐性を示した.
- 耐性菌株ではβ-ラクタマースの活性が検出されなかった.
- 髄膜炎を患ったすべての患者は,感染に屈した.
- セプチセミアの患者は,適切な抗生物質治療の後,生存しました.
結論:
- 主要な抗生物質に耐性を持つ肺炎球菌は,生命を脅かす髄膜炎や結血病を引き起こす可能性があります.
- これらの耐性菌株におけるβ-ラクタマースの欠如は,代替的な耐性メカニズムを示唆する.
- 有効な抗生物質療法は,耐性菌株であっても,肺炎球菌性セプチセミアの症例での生存に不可欠です.
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