甲状腺ホルモンを放出するホルモンに対する過剰な反応と高コレステロール血症との関連
Lancet (London, England)
|November 12, 1977
まとめ
プレミキソエーデマの疑いのある患者は,甲状腺刺激ホルモン (TSH) の過剰な増加を示した. タイロトロフィン放出ホルモン (T.R.H.) に反応する. これらの個人は,対照群と比較して,血清コレステロールのレベルも高かった.
科学分野:
- エンドクリノロジー エンドクリノロジー
- 甲状腺学 甲状腺学について
背景:
- プレミキソエーデマは,甲状腺機能低下症の初期段階を表しています.
- 甲状腺機能障害は,様々な代謝障害につながる可能性があります.
研究 の 目的:
- 疑われるプレミキソエーデマの患者の甲状腺機能を調査する.
- 甲状腺ホルモンの調節と血清コレステロールレベルを,プレミキソエーデマの疑いのある患者と対照群の間で比較する.
主な方法:
- 甲状腺機能検査は,プレミキソエーデマの疑いのある患者100人と,年齢・性別を合わせた対照群20人を対象に実施した.
- 甲状腺を刺激するホルモン (TSH) タイロトロフィン放出ホルモン (T.R.H.) に反応する. 測定されました.
- 血清コレステロール濃度が分析されました.
主要な成果:
- 誇張されたTSHです. T.R.H.に対する反応 プレミキソエデマの疑いのある患者の88%で観察されました.
- この過大反応は,正常な基礎TSHと上昇した基礎TSHの両方の患者で発生しました. レベル,レベル,レベル.
- 血清コレステロールは,血動脈疾患を患っている人を除外した後でも,プレミキソエーデマの疑いのあるグループでは有意に高かった.
結論:
- 微妙な甲状腺機能不全,誇張されたT.R.H.によって示される. 反応は,疑われるプレミキソエーデマで一般的です.
- 血清コレステロールの上昇は,早期の甲状腺機能障害の潜在的代謝結果です.
- これらの発見は,暗示的な症状を持つ患者における早期の甲状腺機能評価の重要性を強調しています.
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