クロフィブラートは,高トリグリセリデミア患者の脂肪組織におけるリポプロテイン-リパース活性を増大させる
Lancet (London, England)
|November 26, 1977
まとめ
クロフィブラート療法は,血トリグリセリドを有意に低下させ,高トリグリセリデミア患者のトリグリセリドクリアランスを増加させた. この薬は脂肪組織のリポプロテインリパース活性を増大させ,脂質代謝を改善した.
科学分野:
- バイオケミストリー バイオケミストリー
- 薬理学 薬理学とは
- メタボリック障害 メタボリック障害
背景:
- ハイパートリグリセリデミアは,血液中のトリグリセリド濃度の上昇によって特徴づけられる状態です.
- リポプロテインリパース (LPL) は,血からのトリグリセリドのクリアランスにおいて重要な役割を果たします.
- 薬がLPL活動に影響するメカニズムを理解することは,高トリグリセリデミアの管理に不可欠です.
研究 の 目的:
- プラズマトリグリセリド濃度およびクリアランスに対するクロフィブラートの効果を調査する.
- 脂肪組織におけるリポプロテインリパース活性に対するクロフィブラート療法の影響を決定する.
主な方法:
- クロフィブラート治療 (2g/日) の1週間前と後の6人の高トリグリセリデミアの患者を研究した.
- 血トリグリセリド濃度とトリグリセリドクリアランスの測定率.
- 脂肪組織におけるヘパリン放出可能および抽出可能リポプロテインリパース活性評価.
主要な成果:
- 血トリグリセリドは6.85 +/- 1.1から2.66 +/- 0.29 mmol/lに大幅に低下しました.
- トリグリセリドのクリアランスは1.3 +/- 0.2から2.4 +/- 0.4%/分に大幅に増加しました.
- 脂肪組織におけるヘパリン放出および抽出可能なLPL活性が,著しく増加した.
結論:
- クロフィブラート療法は,高トリグリセリデミアの患者でプラズマトリグリセリドを効果的に低下させます.
- クロフィブラート作用の重要なメカニズムは,脂肪組織のリポタンパク質リパースレベルを上昇させることである.
- クロフィブラートによるLPL活性強化は,血トリグリセリドのクリアランスを改善します.
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