経口プロプラノロールの左心室のサイズおよび運動および急性圧力負荷中のパフォーマンスに対する効果
Circulation
|March 1, 1980
まとめ
ベータブロッカーである経口プロプラノロールは,健康な個体では心臓筋のパフォーマンスを有意に低下させない. その主な効果は,特に運動中に,心拍数と血圧を低下させることです.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- ベータアドレナージックブロックは,一般的な治療戦略です.
- ベータブロッカーが心筋機能に及ぼす内在的な効果を理解することは極めて重要です.
研究 の 目的:
- 正常な被験者の心筋機能に対する長期の経口プロプラノロル療法の効果を評価する.
- 本質的な心臓効果とベータ・アドレナジック・ブロック効果を区別する.
主な方法:
- 19人の健康な被験者は,2週間にわたって経口プロプラノロール (160 mg/日) を投与された.
- エコーカルディオグラフィーは,休息,運動,圧力負荷の時の心臓機能を評価した.
- フェニレフリンは急性圧力負荷を誘発し,アトロピンは心拍の応答を阻害した.
主要な成果:
- プロプラノロールは,静止時の心拍数と静脈血圧を著しく低下させた.
- 運動中にプロプラノロルは心拍数を減速させ,血圧を下げ,百パーセントの寸法縮小を減少させた.
- 急性圧力負荷の際に,左心室のサイズや機能の有意な差異は観察されなかった.
結論:
- 長期にわたる経口プロプラノロル治療は,正常な被験者の心筋機能に最小限の内在的影響を及ぼします.
- プロプラノロルの主な作用は,運動のような共感的活性化中に明らかなベータ-アドレナergic トーンの抑制です.
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