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関連する概念動画

Membrane Fluidity01:23

Membrane Fluidity

150.1K
Cell membranes are composed of phospholipids, proteins, and carbohydrates loosely attached to one another through chemical interactions. Molecules are generally able to move about in the plane of the membrane, giving the membrane its flexible nature called fluidity. Two other features of the membrane contribute to membrane fluidity: the chemical structure of the phospholipids and the presence of cholesterol in the membrane.
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Membrane Fluidity01:26

Membrane Fluidity

14.0K
Membrane fluidity is explained by the fluid mosaic model of the cell membrane, which describes the plasma membrane structure as a mosaic of components—including phospholipids, cholesterol, proteins, and carbohydrates—that gives the membrane a fluid character.
Mosaic nature of the membrane
The mosaic characteristic of the membrane helps the plasma membrane remain fluid. The integral proteins and lipids exist as separate but loosely-attached molecules in the membrane. The membrane is...
14.0K
Overview of the Vascular System01:20

Overview of the Vascular System

2.7K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.7K
Fluid Connective Tissues: Blood and Lymph01:20

Fluid Connective Tissues: Blood and Lymph

16.7K
Blood and lymph are fluid connective tissues. They contain cells, also known as formed elements, circulating in a liquid extracellular matrix, the plasma. The formed elements are derived from hematopoietic stem cells in the bone marrow. Blood and lymph connect all vital parts and carry nutrients, oxygen, and other essential molecules like antibodies.
Blood
The blood flows through blood vessels— arteries, capillaries, and veins. Blood plasma is primarily made of proteins, solutes, and...
16.7K
Characteristics and Functions of Blood01:26

Characteristics and Functions of Blood

10.3K
Blood is specialized connective tissue comprising about 8% of the body mass. It has a thick, liquid extracellular matrix that contains cells, dissolved proteins, and electrolytes, making it five times more viscous than water. Blood is warm, around 38°C, and has an alkaline pH ranging from 7.35 to 7.45.
The primary function of blood is to transport oxygen and carbon dioxide between tissues and the lungs. Oxygenated blood is bright red, while oxygen-depleted blood is darker. It also carries...
10.3K
Structure and Function of Platelets01:18

Structure and Function of Platelets

7.1K
The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000...
7.1K

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関連する実験動画

Updated: May 5, 2026

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
10:10

Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

Published on: October 27, 2009

21.5K

血小板が,液体および固体のリン酸脂質膜に付着する.

L B Margolis, A N Tikhonov, E Y Vasilieva

    Cell
    |January 1, 1980
    PubMed
    まとめ

    液体フォスフォリピド膜は血小板の粘着を防止し,固体膜はそれを促進する. これは,細胞膜の流動性が,血管壁との望ましくない血小板の相互作用を防ぐために重要であることを示唆しています.

    科学分野:

    • バイオケミストリー バイオケミストリー
    • 細胞生物学 細胞生物学
    • マテリアルサイエンス 材料科学

    背景:

    • 血小板の表面への粘着は,血液静止と血栓形成において極めて重要です.
    • 血小板の相互作用に影響を与えるモデル膜の性質を理解することは,生体材料を開発し,生理学的プロセスを理解するために不可欠です.

    研究 の 目的:

    • リンパ脂膜流動性と血小板粘着の関係について,in vitroで調査する.
    • 膜相移行がモデル膜と血小板の相互作用に影響するかどうかを判断する.

    主な方法:

    • 様々な脂質 (レシチン,フォスファディテイルエタノアミン,スフィンゴミエリン) を用いて,フォスフォリピドモデル膜の製造.
    • 血小板に富んだプラズマを用いて,これらの膜への血小板粘着の評価.
    • 電子回転共振 (ESR) スペクトロスコピーは,膜の相状態 (流体対固体/ゲル) を決定する.
    • 膜を化学的に改造 (クロスリンク) し,その相状態を変更する.

    主要な成果:

    • 流動性フォスフォリピド膜 (相変化温度より上) は,血小板に粘着しなかった.
    • 固体 (ジェル) フォスフォリピド膜 (相変化温度以下) は,血小板に粘着していた.

    さらに関連する動画

    Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
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    An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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    An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

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    関連する実験動画

    Last Updated: May 5, 2026

    Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells
    10:10

    Platelet Adhesion and Aggregation Under Flow using Microfluidic Flow Cells

    Published on: October 27, 2009

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    Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
    08:14

    Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial

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    An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers
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    An In Vitro Assay to Study Platelet Migration Using RGD-Functionalized Avidin-Biotin Tethers

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  • 固体状態を誘発するために交互に結合する膜は,血小板に粘着性を与えました.
  • 結論:

    • 膜の流動性,特に流体から固体への移行は,血小板の粘着を決定する.
    • 内皮細胞のプラズマ膜の流動性は,体内では血小板に対する非粘着性の重要な要因である可能性があります.