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プロプラノロールとディソピラミドの併用経口投与が,健康な男性における心臓機能に与える影響
Circulation
|May 1, 1980
まとめ
ディソピラミドとプロプラノロールは両方とも心筋の収縮性を軽減し,慢性的なディソピラミドはより強い効果を示しています. プロプラノロールはベータ受容体をユニークにブロックし,それらの組み合わせた負のイノトロピック効果は添加的ではありません.
科学分野:
- 心臓病学 心臓病学
- 薬理学 薬理学とは
背景:
- ディソピラミドとプロプラノロールは,心血管への影響が知られている薬です.
- 左心室の機能とβ阻害に対するそれらの個々の影響と組み合わせの影響を理解することは,臨床実務において極めて重要です.
研究 の 目的:
- ディソピラミドとプロプラノロルの単独および同時投与による左心室機能の変化とβ阻害を評価する.
- 単一投与による負のイノトロピー効果と慢性療法による負のイノトロピー効果を比較する.
主な方法:
- 健康な男性ボランティアは,ディソピラミドとプロプラノロールのランダム化薬物療法を受けた.
- 左心室の機能は,エコーカルディオグラフィー (エジェクション分数,シストリック時間間隔) を通じて評価される.
- 運動心拍数の変化によって評価されたベータブロック.
主要な成果:
- 両薬ともネガティブなイノトロピック活性を示し,エジェクション分数のわずかな低下を引き起こした.
- ディソピラミドとプロプラノロルの単一投与は,比較可能なネガティブなイノトロピック効果を示した.
- 慢性的なディソピラミド治療は,慢性的なプロプラノロールよりも大きなネガティブなイノトロピー効果を示した.
- ベータ・アドレノ受容体を阻害する活性を示すのはプロプラノロールのみです.
- 併用投与は,添加的または相乗効果の負のイノトロピー効果をもたらさなかった.
結論:
- ディソピラミドとプロプラノロールは,単一の治療用量で比較可能なネガティブなイノトロピー効果を持っています.
- 慢性的なディソピラミド治療は,慢性的なプロプラノロールよりも顕著なネガティブなイノトロピー効果を発揮します.
- プロプラノロールは,ベータ・アドレノ受容体阻害を示す唯一の薬剤です.
- 併用投与は,ネガティブなイノトロピー作用を強化しない.
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