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Updated: Jul 26, 2026

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)
10:05

Genome-wide Mapping of Drug-DNA Interactions in Cells with COSMIC (Crosslinking of Small Molecules to Isolate Chromatin)

Published on: January 20, 2016

ポリサイクルアロマティック化合物がミトコンドリアおよび核DNAに共性結合する

J A Allen, M M Coombs

    Nature
    |September 18, 1980
    PubMed
    まとめ

    ほとんどの化学がん剤はDNAを改変する. この研究は,多環芳香化合物が,核DNAよりもミトコンドリアDNAに優先的に結合することを明らかにし,癌の発達を理解するための重要な発見です.

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