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ウイルス性疾患とポストペリカルディオトミー症候群. 子どもの将来性研究
Circulation
|December 1, 1980
まとめ
心臓外科手術後のポスト・ペリカルディオトミー症候群 (PPS) は,しばしばウイルス感染症によって引き起こされ,免疫反応を引き起こします. この研究では,抗ウイルス抗体と抗心臓抗体が,PPS患者で同時に現れることが判明しました.
科学分野:
- ペディアトリック・カルディオロジー
- 免疫学 免疫学とは
- 感染症 感染症は感染症です.
背景:
- ポスト・ペリカルディオトミー症候群 (PPS) は,心臓外科手術後の一般的な合併症で,心臓内膜の侵入を伴う.
- PPSの正確な原因は,ウイルスによるものであろうと,免疫によるものであろうと,依然として議論されている.
研究 の 目的:
- ポスト・ペリカルディオトミー症候群 (PPS) のウイルス対免疫学的エチオロギーを調査する.
- PPSにおけるウイルス感染症と抗心臓抗体 (AHA) 発達の役割を評価する.
主な方法:
- 心臓内外科手術を受ける小児患者の前向きのトリプルブラインド研究.
- 抗心臓抗体 (AHA) と抗ウイルス抗体 (AVA) 位数の連続測定.
- PPSの臨床評価と血清学的発見との相関.
主要な成果:
- PPSの総発生率は27%で,2歳未満の乳児では有意に低かった (3.5%).
- 高チーターのAHAは,PPS患者全員に存在していました.
- AVAタイターの有意な上昇は,PPS患者の70%で観察され,ウイルスのトリガーを示唆しました.
結論:
- 新しく発生したか,再活性化した,同時に発生したウイルス病は,PPSに特徴的な免疫反応を誘発する可能性がある.
- この発見は,ポストペリカルジオトミー症候群の双重のウイルスと免疫学的根拠を示唆しています.
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