コトリモクサゾールが正常なクレアチニンクリアランスに与える影響

D Shouval, M Ligumsky, D Ben-Ishay

Lancet (London, England)

|February 4, 1978

まとめ

コートリモクサゾール治療は,正常な腎機能を有する個体において,クレアチニンのクリアランスを有意に低下させ,プラズマクレアチニンを増加させた. 薬の投与を中止すると,腎臓の機能が迅速に回復しました.

科学分野:

薬理学薬理学とは
ネフロロジーはネフロロジーを用います.
クリニカル・メディシン臨床医学

背景:

コートリモクサゾールは広く使用されている抗生物質です.
腎機能に対するその潜在的な影響は,徹底的な調査を必要とします.

研究の目的:

腎臓機能が正常な個体におけるクレアチニンクリアランスに対するコトリモクサゾールの効果を調査する.

主な方法:

腎臓の機能が正常な6人を対象に研究が行われました.
クレアチニンクリアランスとナトリウム分泌は,コートリモクサゾール治療中および中止後にモニタリングされました.

主要な成果:

コートリモクサゾール治療により,クレアチニンクリアランスが平均47ml/min減少 (29%減少) しました.
プラズマクレアチニンの有意な増加 (0.27 mg/dl) が観察されました (P <0.01).
治療中にナトリウム分泌量が22%増加し,治療中断時にベースラインに戻り,抗ナトリウレシスが起こります.

結論:

コートリモクサゾールは腎機能を低下させ,特にクレアチニンクリアランスを低下させることがあります.
腎機能に対する観察された影響は,コトリモクサゾール治療を中止すると逆戻りします.

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