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Updated: Jul 13, 2026

Leveraging Turbidity and Thromboelastography for Complementary Clot Characterization
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Published on: June 4, 2020

タンパク質工学により,トロビンを抗凝固剤に変換する

C S Gibbs1, S E Coutré, M Tsiang

  • 1Gilead Sciences, Foster City, California 94404, USA.

Nature
|November 23, 1995
PubMed
まとめ

E229A置換によるエンジニアリングされたトロンビンは,タンパク質Cを活性化することによって強力な抗凝固剤として作用します.この改変されたトロンビンは,出血のリスクが軽減された抗血栓剤として有望であることが示されています.

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