中年期の血圧レベルと後年期の認知機能の関連性. ホノルル・アジア高齢化研究

L J Launer¹, K Masaki, H Petrovitch

¹National Institute for Public Health and the Environment, Erasmus University Medical School, Bilthoven, The Netherlands.

JAMA

|December 20, 1995

まとめ

中年期における高収縮血圧 (SBP) は,後年における認知機能の低下と関連しています. SBPを早期に管理することは,高齢者の認知機能低下を予防するのに役立ちます.

科学分野:

ゲロントロジーはゲロントロジーの学科です.
心血管の健康についてです.
神経科学は神経科学である.

背景:

中年期の心血管の健康は,後年期の認知機能にとって不可欠であるとますます認識されています.
血圧が認知に及ぼす長期的な影響を理解することは,公衆衛生にとって不可欠です.

研究の目的:

中年期の血圧レベルと高齢の認知機能の関連性を調査する.
中年期のシストリック血圧 (SBP) またはダイアストリック血圧 (DBP) が認知機能低下を予測するかどうかを判断する.

主な方法:

ホノルル・ハート・プログラムから3735人の日本系アメリカ人男性を対象とした縦断的なコホート研究.
1965年から1971年の間に測定された中年のSBPとDBP; 1991年から1993年の間にCognitive Abilities Screening Instrument (CASI) を使用して認知機能を評価した.
年齢,教育,脳卒中,冠動脈疾患,亜臨床性動脈硬化症をコントロールした統計分析.

主要な成果:

中年期におけるより高いSBPは,中年期および後年期における認知機能の低下のリスクの増加と有意に関連していました.
中年のSBPで10mmHg増加するごとに,中期のSBPのリスクが7%増加し,認知機能が低下するリスクが9%増加しました.
心血管系因子への調整は,SBP-認知のリンクを弱めたが排除しなかった;中年のDBPと認知機能との間には関連性が見つかりませんでした.

結論:

中年のSBPは,後年における認知機能低下の有意な予測因子です.
中年のSBPの効果的な管理は,高齢の認知障害のリスクを減らすための重要な戦略かもしれません.

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