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Updated: Aug 8, 2026

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes
12:12

Methods to Assess Beta Cell Death Mediated by Cytotoxic T Lymphocytes

Published on: June 16, 2011

細胞分解性T細胞の細胞毒性は,パーフェリンとFas lytic経路を通じて媒介されます

B Lowin1, M Hahne, C Mattmann

  • 1Institute of Biochemistry, University of Lausanne, Epalinges, Switzerland.

Nature
|August 25, 1994
PubMed
まとめ

細胞分解性Tリンパ球 (CTLs) は,細胞破壊のための2つの経路を利用します:パーフェリン媒介およびFas-リガンドシグナル伝達. 研究者らは,両方の経路を非活性化することで,CTLの活性が完全に廃止され,免疫応答における両者の補完的な役割が明らかになったことを発見しました.

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